Welcome to the BMTInfonet Drug Database

This guide lists many of the drugs bone marrow, stem cell and cord blood transplants patients receive during treatment. It explains why they are used and some, but not allAcute lymphoblastic leukemia., of the possible side effects.

This guide should not be used as a substitute for a detailed discussion with your doctor and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.

Some of the drugs in this guide are also used outside the transplant setting. The descriptions of the drugs in this guide pertain only to their use in bone marrow, stem cell or cord blood transplantation.

If you are searching for a drug used by transplant patients and survivors that is not in this database, please contact us at drugdata@bmtinfonet.org.

This database was compiled under the direction of pharmacists knowledgeable about transplantation, but should not be construed as medical advice. Consult your doctor for information about how each drug might affect you.

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Acetaminophen


Trade Names: 
Tylenol®

Possible Uses: 
Relief of headaches and mild or moderate pain, or to decrease fevers.

Possible Side Effects: 
May mask a fever from an infection. May cause liver damage if dosage exceeds four grams per day.
Last updated on 02/01/2010

Acyclovir


Trade Names: 
Zovirax®

Possible Uses: 
Prevent and treat viral infections, e.g. herpes infections.

Special Notes: 
Available in tablet and injectable form

Drug Interactions: 
Varicella Virus Vaccine- may result in decreased effectiveness

Possible Side Effects: 
Diarrhea, headache, nausea, dizziness, rash, fatigue, change in kidney function, vein irritation, confusion, change in liver function.
Last updated on 02/01/2010

Albuterol


Trade Names: 
Proventil®
Trade Names: 
Ventolin®

Possible Uses: 
Decrease spasms in the airway as with asthma. Often used to help with breathing difficulties.

Possible Side Effects: 
Nervousness, tremor, irregular and fast heartbeat, nausea, dizziness, trouble sleeping, sweating.
Last updated on 02/01/2010

Aldesleukin


Trade Names: 
Proleukin®

Alternate Names: 
IL-2
Alternate Names: 
Interleukin-2

Possible Uses: 
An investigational drug used in BMT to boost the immune system post-transplant and aid it in eliminating any residual tumor cells.

Possible Side Effects: 
Fever, chills, flu-like symptoms, fluid retention, shortness of breath.
Last updated on 02/01/2010

Alemtuzumab


Trade Names: 
Campath®

Possible Uses: 
Approved for B-Cell chronic lymphocytic leukemia. Also used for T-cell lymphoma and leukemia.

Special Notes: 
Can be given by IV infusion and SQ injection

Drug Interactions: 
echinacea

Possible Side Effects: 
Low blood pressure, edema, fever, chills, fatigue, headache,rash, neasuea, vomiting, diarrhea, mucositis. Lymphopenia is significant as well as neutropenia, anemia, and low platelets. Rigors, cough, and infections can occur.
Last updated on 02/01/2010

Allopurinol


Trade Names: 
Zyloprim®

Possible Uses: 
Decreases uric acid that is released when chemotherapy drugs kill tumor cells, protects against kidney damage. Also decreases gout.

Possible Side Effects: 
Fever, chills, drowsiness, nausea vomiting, increased liver function tests, and rash. Rarely, causes a severe rash that progresses to severe burn-like condition called Stevens-Johnson syndrome. May decrease blood cell counts.
Last updated on 02/01/2010

Aluminum Hydroxide


Trade Names: 
AlternaGel®
Trade Names: 
Amphojel®

Possible Uses: 
Relieve stomach irritation, decrease high phosphorous levels in the blood.

Drug Interactions: 
May decrease the effectiveness of certain antibiotics and antifungels. Check with your pharmacist.

Possible Side Effects: 
Constipation, nausea, vomiting, discoloration of stool (white speckles), and chalky taste.
Last updated on 02/01/2010

Amifostine


Trade Names: 
Ethyol®

Possible Uses: 
Protect against kidney damage that may result from cisplatin therapy, and protect against dry mouth associated with head and neck radiation. Investigational use is to protect bone marrow cells from radiation and chemotherapy.

Special Notes: 
Given IV push prior to chemotherapy.

Possible Side Effects: 
Nausea and vomiting, low blood pressure, flushing, sneezing.
Last updated on 02/01/2010

Amikacin


Trade Names: 
Amikin®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Kidney, hearing and/or nerve damage.
Last updated on 02/01/2010

Aminocaproic acid


Trade Names: 
Amicar®

Possible Uses: 
To enhance bleeding control

Special Notes: 
Can be given slow IV infusion or orally.

Possible Side Effects: 
confusion, dizziness,fatigue, headache,rash, stomach pain, cramps, diarrhea, nausea, vomiting. Vision decreased, watery eyes,ringing in the ears,
Last updated on 02/01/2010

Amitriptyline


Trade Names: 
Elavil®

Possible Uses: 
Control depression, promote sleep, control pain that is associated with the nerves.

Possible Side Effects: 
Dry mouth, confusion, constipation, tiredness, dizziness, low blood pressure, heart rhythm changes, blurred vision, difficulty urinating, eye pain, sweating. Rarely, may decrease white blood cell count.
Last updated on 02/01/2010

Amoxicillin


Trade Names: 
Amoxil®
Trade Names: 
Polymox®
Trade Names: 
Trimox®
Trade Names: 
Wymox®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
May decrease the effectiveness of oral contraceptives and increase the effects of anticoagulants such as warfarin or Coumadin®.

Possible Side Effects: 
Diarrhea, rash, nausea, and vomiting. If patient is allergic, may cause rash, swelling, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Amoxicillin/Clavulinate


Trade Names: 
Augmentin®

Possible Uses: 
Prevent or treat bacterial infections. Similar to amoxicillin but treats a wider range of infections.

Drug Interactions: 
May decrease the effectiveness of oral contraceptives and increase the effects of anticoagulants such as warfarin or Coumadin®.

Possible Side Effects: 
Diarrhea, rash, nausea, and vomiting. If patient is allergic, may cause rash, swelling, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Amphotericin B


Trade Names: 
Abelcet®
Trade Names: 
AmBisome®
Trade Names: 
Amphotec®
Trade Names: 
Fungizone®

Possible Uses: 
Prevent or treat fungal infections.

Possible Side Effects: 
Fever, chills, muscle shaking, nausea, vomiting, decreased electrolytes (especially potassium and magnesium), decreased blood pressure, shortness of breath, decreased kidney function, diarrhea, rash, and anemia.
Last updated on 02/01/2010

Ampicillin


Trade Names: 
Omnipen®
Trade Names: 
Polycillin®
Trade Names: 
Principen®
Trade Names: 
Totacillin®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
May decrease the effectiveness of oral contraceptives and may increase the effects of anticoagulants such as warfarin or Coumadin®.

Possible Side Effects: 
Diarrhea, rash, nausea, vomiting. If patient has a penicillin allergy, may cause rash, swelling, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Ampicillin/Sulbactam


Trade Names: 
Unasyn®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
May decrease the effectiveness of oral contraceptives and may increase the effects of anticoagulants such as warfarin or Coumadin®.

Possible Side Effects: 
Diarrhea, rash, nausea, and vomiting. If patient has a penicillin allergy, may cause rash, swelling, or breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Antithymocyte Globulin


Trade Names: 
Atgam®
Trade Names: 
Thymogobulin®

Alternate Names: 
ATG
Alternate Names: 
Lymphocyte Immune Globulin

Possible Uses: 
Used in allogeneic transplants to treat or prevent graft-versus-host disease (GVHD).

Special Notes: 
Atgam is derived from horse serum and Thymoglobulin is derived from rabbit serum.

Possible Side Effects: 
Fever, chills, decreased or increased blood pressure, chest pain, fast heart beat, nausea, shortness of breath, diarrhea, irritation at injection site, decline in kidney function, swelling of mouth and throat.
Last updated on 02/01/2010

Aprepitant


Trade Names: 
Emend®

Possible Uses: 
to prevent nausea and vomiting from chemotherapy

Special Notes: 
Can be given IV or orally

Drug Interactions: 
Avoid grapefruit juice or grapefuits while taking this medication. This drug may interfere with many drugs, please consult your pharmacist as needed

Possible Side Effects: 
Fatigue, constipation, hiccups, dizziness, diarrhea
Last updated on 02/01/2010

Atovaquone


Trade Names: 
Mepron®

Possible Uses: 
Use to prevent a pulmonary infection known as PCP

Special Notes: 
available as a suspension only

Drug Interactions: 
Must be taken with meals

Possible Side Effects: 
Fever, headache, insomnia, rash, diarrhea, nausea, vomiting, stomach pain,muscle aches, cough, dizziness, high blood sugar,constipation.
Last updated on 02/01/2010

Azithromycin


Trade Names: 
Zithromax®
Trade Names: 
Z-Pak®

Possible Uses: 
Treat or prevent infection.

Drug Interactions: 
Interferes with many drugs metabolized by the liver. May be toxic to the heart when used with quinidine. Do not take with calcium supplements or antacids.

Possible Side Effects: 
Diarrhea, abdominal pain and cramping, nausea, vomiting, liver dysfunction, heart beat irregularity, rash.
Last updated on 02/01/2010

Aztreonam


Trade Names: 
Azactam®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Diarrhea, nausea, vomiting, rash, pain at injection site, change in liver function tests. If patient is allergic, may cause rash, swelling, breathing difficulties.
Last updated on 02/01/2010

Cefazolin


Trade Names: 
Ancef®
Trade Names: 
Kefzol®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Diarrhea, nausea, vomiting, or rash. If patient is allergic, may cause rash, swelling, breathing difficulties.
Last updated on 02/01/2010

Cytarabine


Trade Names: 
Cytosar-U®

Alternate Names: 
Cytosine Arabinoside
Alternate Names: 
ara-C

Possible Uses: 
Chemotherapy drug.

Possible Side Effects: 
Nausea, vomiting, diarrhea, rash, temporary hair loss, mouth sores, stomach cramps, loss of appetite, yellow skin or eyes, sensitivity to light, flu-like feeling, temporary liver disorder, breathing difficulties. High doses of this drug can cause confusion, dizziness, and inflammation and pain of the eyes.
Last updated on 02/01/2010

Doxepin


Trade Names: 
Adapin®
Trade Names: 
Sinequan®

Possible Uses: 
Relieve depression, treat pain associated with the nerves.

Possible Side Effects: 
Dry mouth, constipation, confusion, drowsiness, dizziness, nausea, blurred vision, sensitivity to sunlight, low blood pressure, heart rhythm changes, hives, swelling of face, lips or tongues, difficulty urinating, hallucinations.
Last updated on 02/01/2010

Doxorubicin


Trade Names: 
Doxil®
Trade Names: 
Adriamycin®
Trade Names: 
Rubex®

Possible Uses: 
A chemotherapy drug.

Drug Interactions: 
Inj. dexrazoxane can be given to prevent heart toxicities of doxorubicin.

Possible Side Effects: 
Decreased blood counts, temporary hair loss, mouth sores, loss of appetite, flu-like symptoms, heart damage, breathing difficulties, swelling in legs and feet, rash, itching, nausea, vomiting, diarrhea. May cause temporary orange or red color in urine and secretions (tears, mucous). When doxorubicin leaks outside the vein severe skin damage can occur.
Last updated on 02/01/2010

Fentanyl


Trade Names: 
Actiq®
Trade Names: 
Duragesic®
Trade Names: 
Sublimaze®
Trade Names: 
Onsolis®

Possible Uses: 
Relieve severe or long-term pain.

Possible Side Effects: 
Constipation, nausea, vomiting, drowsiness, confusion, dry mouth, stomach pain, rash, itching, swelling, breathing difficulties, irregular heartbeat, chest pain.
Last updated on 02/01/2010

Ibuprofen


Trade Names: 
Advil®
Trade Names: 
Haltran®
Trade Names: 
Medipren®
Trade Names: 
Motrin®
Trade Names: 
Nuprin®
Trade Names: 
Profen®
Trade Names: 
Rufen®

Possible Uses: 
Relieve minor pain and pain associated with inflammation.

Possible Side Effects: 
Nausea, vomiting, bloody urine, stool or vomit, rash, red peeling skin, swelling in face or around the eyes, reduced kidney function, poor platelet function, liver toxicity, stomach pain, dizziness, ringing in ears, swelling in feet or legs. Used only when absolutely necessary, and then with great care, due to bleeding risks.
Last updated on 02/01/2010

Lorazepam


Trade Names: 
Ativan®

Possible Uses: 
Decrease anxiety, control nausea and vomiting.

Possible Side Effects: 
Agitation, irritability, difficulty concentrating, memory loss, drowsiness, dizziness, blurred vision, breathing difficulties, muscle weakness, slurred speech.
Last updated on 02/01/2010

Melphalan


Trade Names: 
Alkeran®

Possible Uses: 
Used as a chemotherapy drug, often for lymphomas and myelomas. Also used as high-dose therapy conditioning regimen for multiple myeloma.

Special Notes: 
Given as tablet or injection

Possible Side Effects: 
Nausea, vomiting, diarrhea, mouth sores, temporary hair loss, lung disorder (often reversible), skin inflammation, liver disorder (often reversible).
Last updated on 02/01/2010

Naproxen


Trade Names: 
Aleve®
Trade Names: 
Anaprox®
Trade Names: 
Naprosyn®

Possible Uses: 
Relieve headaches, nerve and bone pain, and reduce inflammation.

Possible Side Effects: 
Nausea, vomiting, rash, swelling of face or around eyes, chest tightness, breathing difficulties, fever, sore throat, yellowing of skin or eyes, decreased urine output, stomach pain, bloody vomit, black or bloody stool, drowsiness, dizziness, ringing in ears, headache, heartburn, swollen feet or legs, constipation, diarrhea, stomach/intestinal bleeding, reduced kidney function, poor platelet function, liver toxicity. Used only when absolutely necessary, and then with great care, due to bleeding risks.
Last updated on 02/01/2010