Welcome to the BMTInfonet Drug Database

This guide lists many of the drugs bone marrow, stem cell and cord blood transplants patients receive during treatment. It explains why they are used and some, but not allAcute lymphoblastic leukemia., of the possible side effects.

This guide should not be used as a substitute for a detailed discussion with your doctor and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.

Some of the drugs in this guide are also used outside the transplant setting. The descriptions of the drugs in this guide pertain only to their use in bone marrow, stem cell or cord blood transplantation.

If you are searching for a drug used by transplant patients and survivors that is not in this database, please contact us at drugdata@bmtinfonet.org.

This database was compiled under the direction of pharmacists knowledgeable about transplantation, but should not be construed as medical advice. Consult your doctor for information about how each drug might affect you.

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Aldesleukin


Trade Names: 
Proleukin®

Alternate Names: 
IL-2
Alternate Names: 
Interleukin-2

Possible Uses: 
An investigational drug used in BMT to boost the immune system post-transplant and aid it in eliminating any residual tumor cells.

Possible Side Effects: 
Fever, chills, flu-like symptoms, fluid retention, shortness of breath.
Last updated on 02/01/2010

Ibuprofen


Trade Names: 
Advil®
Trade Names: 
Haltran®
Trade Names: 
Medipren®
Trade Names: 
Motrin®
Trade Names: 
Nuprin®
Trade Names: 
Profen®
Trade Names: 
Rufen®

Possible Uses: 
Relieve minor pain and pain associated with inflammation.

Possible Side Effects: 
Nausea, vomiting, bloody urine, stool or vomit, rash, red peeling skin, swelling in face or around the eyes, reduced kidney function, poor platelet function, liver toxicity, stomach pain, dizziness, ringing in ears, swelling in feet or legs. Used only when absolutely necessary, and then with great care, due to bleeding risks.
Last updated on 02/01/2010

Idarubicin


Trade Names: 
Idamycin®

Possible Uses: 
A chemotherapy drug.

Possible Side Effects: 
Nausea, vomiting, diarrhea, stomach cramps, mouth sores, fever, chills, sore throat, stomach pain, blood in stool, breathing difficulties, heart damage, swelling in feet or legs, rash, itching, loss of appetite, headache. When idarubicin leaks outside the vein severe skin damage can occur.
Last updated on 02/01/2010

Ifosfamide


Trade Names: 
Ifex®

Possible Uses: 
A chemotherapy drug.

Special Notes: 
Should be administered with MESNA to prevent bladder damage.

Possible Side Effects: 
Nausea, vomiting, diarrhea, upset stomach, loss of appetite, temporary hair loss, pain when urinating, bloody urine, bladder irritation, irregular or fast heartbeat, mouth sores, reversible kidney disorder, confusion, drowsiness, dizziness, seizures.
Last updated on 02/01/2010

Imatinib


Trade Names: 
Gleevec®

Possible Uses: 
CML (chronic myelogenous leukemia), Philadelphia + ALL, Gastrointestinal stromal tumors (GIST)

Special Notes: 
take with food and a full glass of water to decrease nausea and stomach upset

Drug Interactions: 
possible interactions with warfarin, phenytoin, carbamazepine, rifampin, phenobarbital, ketoconazole, itraconazole, erythromycin, clarithromycin, and St. John's wort

Possible Side Effects: 
nausea, fluid retention (especially around eyes and ankles), weight gain, diarrhea, neutropenia, thrombocytopenia, may alter liver function testing, skin rashes, which can be severe
Last updated on 02/01/2010

Imipenem


Trade Names: 
Primaxin®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Rash, vein irritation, nausea, vomiting. If patient is allergic, may cause breathing difficulties, swelling of face, throat or lips, rash.
Last updated on 02/01/2010

Imipramine


Trade Names: 
Tofranil®

Possible Uses: 
Control depression and nerve pain.

Possible Side Effects: 
Dry mouth, constipation, confusion, sleepiness, low blood pressure, heart rhythm changes, rash, difficulty urinating, dizziness, nausea, vision problems. May suppress stem cell engraftment.
Last updated on 02/01/2010

Immune Globulin


Trade Names: 
Gamimune N®
Trade Names: 
Gammagard®
Trade Names: 
Gammar-IV®
Trade Names: 
Iveegam®
Trade Names: 
PolyGam®
Trade Names: 
Sandoglobulin®
Trade Names: 
Venoglobulin®

Alternate Names: 
IGG
Alternate Names: 
IVIG

Possible Uses: 
Prevent or treat infection while immune system is weak.

Special Notes: 
A product derived from human blood collections.

Possible Side Effects: 
Fever, chills, allergic reaction, rash, flushing, tightness in chest, dizziness, nausea, vomiting, increased blood pressure, headache, fatigue, pain in back, hip or joints, kidney damage.
Last updated on 02/01/2010

Infliximab


Trade Names: 
Remicade®

Possible Uses: 
Approved to treat ulcerative colitis and rheumatoid arthritis. Unlabeld use in BMT is for severe GI tract GVHD not controlled by steroids

Special Notes: 
In GVHD treatment the drug can be given weekly for 4-8 weeks

Drug Interactions: 
Avoid echinacea

Possible Side Effects: 
Headache, nausea, diarrhea, stomach pain, infections,high blood pressure, rash, upset stomach, bronchitis, anemia,flushing.
Last updated on 02/01/2010

Interferon Alfa


Trade Names: 
Intron®
Trade Names: 
Roferon®

Alternate Names: 
IFN-A

Possible Uses: 
A commercially available drug that is used in an "off-label" use before and/or after transplants for patients with certain diseases to prolong remission. Also used with ribavirin to treat hepatitis C.

Possible Side Effects: 
Flu-like feeling, fatigue, fever, chills, muscle aches, loss of appetite, irregular heartbeat, numbness or tingling in hands or feet, nausea, vomiting, weight loss, dry mouth, dry throat, change in taste. Rarely, heart failure.
Last updated on 02/01/2010

Interleukin-eleven


Trade Names: 
Neumega®

Alternate Names: 
IL-eleven

Possible Uses: 
Speed platelet recovery after transplant.

Possible Side Effects: 
Fluid retention, heart rhythm abnormalities.
Last updated on 02/01/2010

Itraconazole


Trade Names: 
Sporonox®

Possible Uses: 
Prevent or treat fungal infection.

Drug Interactions: 
This drug may interfer with many drugs. Please check with your pharmacist

Possible Side Effects: 
Upset stomach, nausea, vomiting, diarrhea, headache, dizziness, drowsiness, yellow skin or eyes, dark colored urine, clay colored bowel movements, rash, itching.
Last updated on 02/01/2010

Oprelvekin


Trade Names: 
Neumega®

Alternate Names: 
IL-eleven

Possible Uses: 
Speed platelet recovery after transplant, though not approved by FDA

Possible Side Effects: 
Fluid retention, heart rhythm abnormalities, allergic reactions
Last updated on 02/01/2010
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