Welcome to the BMTInfonet Drug Database

This guide lists many of the drugs bone marrow, stem cell and cord blood transplants patients receive during treatment. It explains why they are used and some, but not allAcute lymphoblastic leukemia., of the possible side effects.

This guide should not be used as a substitute for a detailed discussion with your doctor and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.

Some of the drugs in this guide are also used outside the transplant setting. The descriptions of the drugs in this guide pertain only to their use in bone marrow, stem cell or cord blood transplantation.

If you are searching for a drug used by transplant patients and survivors that is not in this database, please contact us at drugdata@bmtinfonet.org.

This database was compiled under the direction of pharmacists knowledgeable about transplantation, but should not be construed as medical advice. Consult your doctor for information about how each drug might affect you.

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Antithymocyte Globulin


Trade Names: 
Atgam®
Trade Names: 
Thymogobulin®

Alternate Names: 
ATG
Alternate Names: 
Lymphocyte Immune Globulin

Possible Uses: 
Used in allogeneic transplants to treat or prevent graft-versus-host disease (GVHD).

Special Notes: 
Atgam is derived from horse serum and Thymoglobulin is derived from rabbit serum.

Possible Side Effects: 
Fever, chills, decreased or increased blood pressure, chest pain, fast heart beat, nausea, shortness of breath, diarrhea, irritation at injection site, decline in kidney function, swelling of mouth and throat.
Last updated on 02/01/2010

Cladribine


Trade Names: 
Leustatin®

Alternate Names: 
2-CdA

Possible Uses: 
This agent is chemotherapy. It is used to treat hairy cell leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, and non-Hodgkin's lymphomas.

Possible Side Effects: 
Fever, tiredness, headache, rash nausea, vomiting, decrease in infection fighting cells causing increase potential for infections, decrease in your red blood cells which will cause fatigue, decrease in your platlets which will cause increase your risk for bleeding or easy bruising, injection site reactions, infection, rapid heart beats, dizziness, chills, rash, diarrhea, constipation, abdominal pain, breathing diffiuclties
Last updated on 02/01/2010

Diphenoxylate with Atropine


Trade Names: 
Logen®
Trade Names: 
Lomenate®
Trade Names: 
Lomotil®
Trade Names: 
Lonox®
Trade Names: 
Lo-Trol®
Trade Names: 
Nor-Mil®

Possible Uses: 
Used to control diarrhea. Is not available over the counter.

Possible Side Effects: 
Nausea, vomiting, decreased urination, constipation, sweating, itchy skin, slowed breathing, drowsiness, dizziness, restlessness, dry mouth, blurred vision, headache, irregular or fast heartbeat, seizures.
Last updated on 02/01/2010

Furosemide


Trade Names: 
Lasix®

Possible Uses: 
Increase urine production and decrease water in body.

Possible Side Effects: 
Decreased potassium, decreased blood pressure, dizziness, rash, itching, decreased sodium, chloride and magnesium. Persons allergic to sulfa drugs may have an allergic reaction.
Last updated on 02/01/2010

Lansoprazole


Trade Names: 
Prevacid®

Possible Uses: 
treatment or prevention of ulcers, reflux

Special Notes: 
take before eating, best before breakfast

Drug Interactions: 
possible interaction with Plavix (clopidogrel), Sprycel (dasatinib) and other medications, review with healthcare provider or pharmacist

Possible Side Effects: 
headache, constipation, diarrhea, abdominal pain
Last updated on 02/01/2010

Lenalidomide


Trade Names: 
Revlimid®

Possible Uses: 
myelodysplastic syndrome (MDS), multiple myeloma

Special Notes: 
Only available thru RevAssist distribution program (prescriber, pharmacist, and patient must be registered). Lenalidomide can cause severe or fatal birth defects. Two forms of birth control must be used. Blood or semen should not be donated during treatment. Breast feeding should be avoided.

Possible Side Effects: 
neutropenia, thrombocytopenia, increased risk of blood clots, nausea, vomiting, diarrhea, constipation
Last updated on 02/01/2010

Leucovorin


Trade Names: 
Wellcovorin®

Alternate Names: 
Tetra-hydrofolate

Possible Uses: 
This drug is a folic acid derviative. Used to rescue cells from excess methotrexate blood levels.

Possible Side Effects: 
Flushed face, warm feeling.
Last updated on 02/01/2010

Levofloxacin


Trade Names: 
Levaquin®

Possible Uses: 
Prevent or treat bacterial infection.

Drug Interactions: 
Avoid calcium supplements, antacids, and dairy products one hour before or two hours after taking.

Possible Side Effects: 
Stomach upset, nausea, vomiting, diarrhea, sensitivity to sunlight, headache, dizziness, change in kidney or liver function (generally temporary). Rarely, may cause seizures. If patient is allergic, may cause breathing difficulties, rash, swelling of face, throat or lips.
Last updated on 02/01/2010

Lidocaine


Trade Names: 
Xylocaine®

Possible Uses: 
Numb the skin during a bone marrow biopsy. An oral version is used to relieve painful mouth sores.

Possible Side Effects: 
Irritation at the site of injection and, when taken orally, it may interfere with the ability to swallow.
Last updated on 02/01/2010

Linezolid


Trade Names: 
Zyvox®

Possible Uses: 
Antibiotic used for the treatment of resistant gram-positive infections (e.g. vancomycin-resistant Enterococcus faecium - VRE)

Drug Interactions: 
Avoid alcohol and tyramine containing foods

Possible Side Effects: 
nausea, vomiting, diarrhea, altered taste, insomnia, dizziness, rash, headache, neutropenia, thrombocytopenia
Last updated on 02/01/2010

Lorazepam


Trade Names: 
Ativan®

Possible Uses: 
Decrease anxiety, control nausea and vomiting.

Possible Side Effects: 
Agitation, irritability, difficulty concentrating, memory loss, drowsiness, dizziness, blurred vision, breathing difficulties, muscle weakness, slurred speech.
Last updated on 02/01/2010

Sargramostim


Trade Names: 
Leukine®

Alternate Names: 
GM-CSF

Possible Uses: 
Speed recovery of white blood cell count after transplant. Also used to move stem cells from bone marrow into the bloodstream prior to a stem cell harvest.

Possible Side Effects: 
Reaction at injection site, chills, fever, bone pain, muscle ache, rash, itching, swelling, fatigue, headache, flushing, nausea, vomiting, diarrhea. Rarely, breathing difficulties, fast or slow or irregular heartbeat.
Last updated on 02/01/2010

Vancomycin


Trade Names: 
Lyphocin®
Trade Names: 
Vancocin®
Trade Names: 
Vancoled®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Rash, vein irritation, decrease in kidney function, stomach upset, nausea, diarrhea, dizziness, ringing in the ears, hearing difficulties. If patient is allergic, may cause swollen face, throat or lips, breathing difficulties. If infused too quickly, may cause a flushing and reddening of the skin. This is known as 'red man's syndrome' and is not an allergic reaction.
Last updated on 02/01/2010
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