Welcome to the BMTInfonet Drug Database

This guide lists many of the drugs bone marrow, stem cell and cord blood transplants patients receive during treatment. It explains why they are used and some, but not allAcute lymphoblastic leukemia., of the possible side effects.

This guide should not be used as a substitute for a detailed discussion with your doctor and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.

Some of the drugs in this guide are also used outside the transplant setting. The descriptions of the drugs in this guide pertain only to their use in bone marrow, stem cell or cord blood transplantation.

If you are searching for a drug used by transplant patients and survivors that is not in this database, please contact us at drugdata@bmtinfonet.org.

This database was compiled under the direction of pharmacists knowledgeable about transplantation, but should not be construed as medical advice. Consult your doctor for information about how each drug might affect you.

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Atovaquone


Trade Names: 
Mepron®

Possible Uses: 
Use to prevent a pulmonary infection known as PCP

Special Notes: 
available as a suspension only

Drug Interactions: 
Must be taken with meals

Possible Side Effects: 
Fever, headache, insomnia, rash, diarrhea, nausea, vomiting, stomach pain,muscle aches, cough, dizziness, high blood sugar,constipation.
Last updated on 02/01/2010

Busulfan


Trade Names: 
Myleran®
Trade Names: 
Busulfex®

Possible Uses: 
Chemotherapy drug for patients with myelogenous leukemia. Used in larger doses as a conditioning agent in AML patients.

Special Notes: 
Can be given IV or orally.

Possible Side Effects: 
Decreased blood counts, nausea, diarrhea, vomiting, temporary hair loss, increase in liver function tests, infertility, cessation of menstruation, dark spots on skin, itching, cataracts, seizures, lung damage. Larger doses may cause seizures.
Last updated on 02/01/2010

Cefepime


Trade Names: 
Maxipime®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Diarrhea, nausea, vomiting, pain and inflammation at injection site, fever, headache, rash, temporary increase in liver function tests, blurred vision. If patient is allergic, may cause rash, swelling, or breathing difficulties.
Last updated on 02/01/2010

Clotrimazole


Trade Names: 
Mycelex®

Possible Uses: 
Prevent/control fungal infections in the mouth and throat.

Special Notes: 
Dissolve troche slowly and completely in the mouth. Do not swallow.

Possible Side Effects: 
Change in taste, upset stomach, nausea, vomiting, temporary change in liver function.
Last updated on 02/01/2010

Ibuprofen


Trade Names: 
Advil®
Trade Names: 
Haltran®
Trade Names: 
Medipren®
Trade Names: 
Motrin®
Trade Names: 
Nuprin®
Trade Names: 
Profen®
Trade Names: 
Rufen®

Possible Uses: 
Relieve minor pain and pain associated with inflammation.

Possible Side Effects: 
Nausea, vomiting, bloody urine, stool or vomit, rash, red peeling skin, swelling in face or around the eyes, reduced kidney function, poor platelet function, liver toxicity, stomach pain, dizziness, ringing in ears, swelling in feet or legs. Used only when absolutely necessary, and then with great care, due to bleeding risks.
Last updated on 02/01/2010

Maalox®


Possible Uses: 
Control stomach irritation.

Possible Side Effects: 
Diarrhea, white colored stool, stomach pain. Rarely, constipation.
Last updated on 02/01/2010

Magnesium Supplements


Alternate Names: 
magnesium oxide
Alternate Names: 
magnesium protein plus

Possible Uses: 
Treatment of low blood magnesium levels

Drug Interactions: 
May interfere with the absorption of many medications, including mycophenolate, ciprofloxacin and other quinolone antibiotics. Should be separated by 2 to 4 hours.

Possible Side Effects: 
Diarrhea, nausea, elevated blood magnesium levels
Last updated on 02/01/2010

Megestrol


Trade Names: 
Megace®

Possible Uses: 
This is a progesterone type drug. Used to stimulate appetite, treat breast cancer.

Possible Side Effects: 
Nausea, vomiting, diarrhea, gas, increased blood pressure, weakness, insomnia, headache, slurred speech, change in vision, swollen feet and ankles, weight gain, rash.
Last updated on 02/01/2010

Melphalan


Trade Names: 
Alkeran®

Possible Uses: 
Used as a chemotherapy drug, often for lymphomas and myelomas. Also used as high-dose therapy conditioning regimen for multiple myeloma.

Special Notes: 
Given as tablet or injection

Possible Side Effects: 
Nausea, vomiting, diarrhea, mouth sores, temporary hair loss, lung disorder (often reversible), skin inflammation, liver disorder (often reversible).
Last updated on 02/01/2010

Meperidine


Trade Names: 
Demerol®

Possible Uses: 
Relieve moderate to severe pain, relieve or prevent chills caused by platelet transfusions or amphotericin B.

Special Notes: 
As a pain reliever it is not useful for long lasting pain. Do not use if you have kidney problems.

Possible Side Effects: 
Dizziness, drowsiness, itching, constipation, nausea, vomiting, diarrhea, nervousness, irritability, confusion, hallucinations, tremors, seizures, difficulty urinating, slow, fast or irregular heartbeat, rash, breathing difficulties.
Last updated on 02/01/2010

Mesna


Trade Names: 
Mesnex®

Alternate Names: 
MESNA

Possible Uses: 
Prevent kidney damage from cyclophosphamide or ifosfamide.

Possible Side Effects: 
Bad taste in mouth, nausea, vomiting, diarrhea, headache, rash, itching, decreased blood pressure.
Last updated on 02/01/2010

Methotrexate


Trade Names: 
Folex PFS®
Trade Names: 
Rheumatrex®

Alternate Names: 
MTX

Possible Uses: 
Chemotherapy drug used in many cancers. Interfers with the way the body uses folic acid. Often used after a transplant to prevent graft vs host disease.

Drug Interactions: 
probeneicd, peniccillins. Folic aid, NSAIDs,

Possible Side Effects: 
Nausea, vomiting, diarrhea, temporary hair loss, mouth sores, headache, fever, chills, sore throat, loss of appetite, breathing difficulties, rash, itching, yellow eyes or skin, dark urine, decreased urine output.
Last updated on 02/01/2010

Methylprednisolone


Trade Names: 
Medrol®
Trade Names: 
Solu-Medrol®

Possible Uses: 
Decrease swelling and allergic reactions, control nausea and vomiting, or may be used as part of a chemotherapy regimen. In allogeneic transplants, used to prevent graft rejection.

Possible Side Effects: 
Fluid retention, weight gain, increase in blood sugar, increase in white cell count, restlessness, anxiety, mood changes, sweating, redness in face, thinning skin, acne, increased hair growth, irregular menstrual periods, black bowel movements, muscle weakness or cramps.
Last updated on 02/01/2010

Metronidazole


Trade Names: 
Flagyl®

Possible Uses: 
Prevent or treat bacterial infection.

Drug Interactions: 
Avoid the use of alcohol when using this drug. Use with alcohol may cause reactions including sweating, nausea, vomiting, heart palpitations, headache, and flushing. May interact with warfarin (Coumadin), resulting in increased risk of bleeding.

Possible Side Effects: 
Nausea, vomiting, diarrhea, headache, dark colored urine, stomach upset, metallic taste, itching, rash.
Last updated on 02/01/2010

Mezlocillin


Trade Names: 
Mezlin®

Possible Uses: 
Prevent or treat bacterial infection.

Possible Side Effects: 
Nausea, vomiting, diarrhea, rash, bleeding problems, change in kidney or liver function. If patient is allergic, may cause swollen face, throat or lips, or breathing difficulties. May cause a superinfection such as a vaginal fungal infection.
Last updated on 02/01/2010

Midazolam


Trade Names: 
Versed®

Possible Uses: 
To provide sedation, decrease anxiety prior to procedures or daignostic testing

Drug Interactions: 
may see increased sedation when used with other drugs which cause sedation, such as opioid narcotics

Possible Side Effects: 
Decreased blood pressure, breathing difficulties, nausea, vomiting, hallucinations, confusion, drowsiness.
Last updated on 02/01/2010

Mitomycin C


Trade Names: 
Mutamycin®

Possible Uses: 
Chemotherapy drug.

Possible Side Effects: 
Nausea, vomiting, diarrhea, mouth sores, temporary hair loss, darkening of skin, skin ulcers, irregular heartbeat, fever, chills, sore throat, decreased urine output, breathing difficulties, swollen feet or ankles, rash, itching, stomach cramps, loss of appetite, infertility.
Last updated on 02/01/2010

Mitoxantrone


Trade Names: 
Novantrone®

Possible Uses: 
Chemotherapy drug.

Possible Side Effects: 
Mouth sores, temporary hair loss, nausea, vomiting, diarrhea, blue-green discoloration of skin, urine and nail beds, reversible liver disorder, fever, chills, sore throat, heart damage, breathing difficulties, swollen feet or ankles, rash, itching.
Last updated on 02/01/2010

Morphine


Trade Names: 
MSContin®
Trade Names: 
MSIR®
Trade Names: 
Oramorph SR®
Trade Names: 
Roxanol®

Possible Uses: 
Relieve moderate to severe pain.

Possible Side Effects: 
Constipation, nausea, itching, vomiting, dizziness, weakness, dry mouth, headache, blurred vision, sleepiness, rapid or slow heartbeat, breathing difficulties, swollen face, rash, hallucinations, change in behavior, confusion, tender stomach.
Last updated on 02/01/2010

Mycophenolate


Trade Names: 
CellCept®

Possible Uses: 
Used after allogeneic stem cell transplant to prevent graft vs host disease

Drug Interactions: 
The effects of mycophenolate may be decreased by antacids, magnesium salts, metronidazole, cyclosporin. Avoid cat's claw and echinacea

Possible Side Effects: 
abdominal pain, anemia, diarrhea, constipation, fever, high blood pressure, low blood pressure, chest pain, low white blood cell counts, anemia, infections, nausea, vomiting, rash. Possible liver and kidney dysfunction. High blood sugar and high cholestrol levels. Low magnesium, potassium, and calcium levels.
Last updated on 02/01/2010

Mylanta®


Possible Uses: 
Control stomach irritation.

Possible Side Effects: 
Diarrhea, white colored stool, stomach pain. Rarely, constipation.
Last updated on 02/01/2010

Nystatin


Trade Names: 
Mycostatin®
Trade Names: 
Nilstat®

Possible Uses: 
Prevent or treat fungal infections in the mouth or on the skin.

Special Notes: 
When taken orally the drug works by being in contact with the mucous membranes. Swish in mouth for at least 30 seconds.

Possible Side Effects: 
Stomach upset, nausea, vomiting, diarrhea, change in taste.
Last updated on 02/01/2010

Plerixafor


Trade Names: 
Mozobil®

Possible Uses: 
Use to help mobilize stem cells for collection and subequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma

Special Notes: 
This drug is normally given by SQ injection 12 hours prior to collection of stem cells

Drug Interactions: 
no known significant drug interactions

Possible Side Effects: 
fatigue, headache, dizziness, diarrhea, nausea, injection site reactions, and muscle aches, vomiting
Last updated on 02/01/2010
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