Welcome to the BMTInfonet Drug Database

This guide lists many of the drugs bone marrow, stem cell and cord blood transplants patients receive during treatment. It explains why they are used and some, but not allAcute lymphoblastic leukemia., of the possible side effects.

This guide should not be used as a substitute for a detailed discussion with your doctor and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.

Some of the drugs in this guide are also used outside the transplant setting. The descriptions of the drugs in this guide pertain only to their use in bone marrow, stem cell or cord blood transplantation.

If you are searching for a drug used by transplant patients and survivors that is not in this database, please contact us at drugdata@bmtinfonet.org.

This database was compiled under the direction of pharmacists knowledgeable about transplantation, but should not be construed as medical advice. Consult your doctor for information about how each drug might affect you.

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Cyclophosphamide


Trade Names: 
Cytoxan®
Trade Names: 
Neosar®

Possible Uses: 
Chemotherapy drug.

Possible Side Effects: 
Nausea, vomiting, temporary hair loss, mouth sores, infertility, darkened skin or fingernails, swollen feet or ankles, tiredness, breathing problems, bloody urine, irregular or fast heartbeat, lung disorder (usually reversible). Large doses of the drug may cause bladder irritation which can result in pain and bleeding. MESNA is used to prevent bladder irritation from cyclophosphamide.
Last updated on 02/01/2010

Cyclosporine A


Trade Names: 
Neoral®
Trade Names: 
Sandimune®

Possible Uses: 
In allogeneic transplantation, used to prevent or treat graft-versus-host disease (GVHD).

Drug Interactions: 
Avoid grapefruit juice. Take at the same time each day. There are many drugs that may decrease or increase blood levels. Check with pharmacist.

Possible Side Effects: 
High blood pressure, decreased kidney function, muscle tremor, enlargement of the gums, seizure, acne, leg cramps, abdominal discomfort, diarrhea, nausea, vomiting.
Last updated on 02/01/2010

Diphenoxylate with Atropine


Trade Names: 
Logen®
Trade Names: 
Lomenate®
Trade Names: 
Lomotil®
Trade Names: 
Lonox®
Trade Names: 
Lo-Trol®
Trade Names: 
Nor-Mil®

Possible Uses: 
Used to control diarrhea. Is not available over the counter.

Possible Side Effects: 
Nausea, vomiting, decreased urination, constipation, sweating, itchy skin, slowed breathing, drowsiness, dizziness, restlessness, dry mouth, blurred vision, headache, irregular or fast heartbeat, seizures.
Last updated on 02/01/2010

Filgrastim


Trade Names: 
Neupogen®

Alternate Names: 
G-CSF

Possible Uses: 
Increase the number of stem cells available for harvest in the bloodstream; speed recovery of white blood cell counts after transplant.

Possible Side Effects: 
Bone pain, nausea, loss of appetite, fever, chills, sore throat, rash, itching, swelling in face, lips or throat, breathing difficulties, fast or irregular heartbeat, pain at injection site, enlarged spleen.
Last updated on 02/01/2010

Gabapentin


Trade Names: 
Neurontin®

Possible Uses: 
Prevent or treat seizures, treat nerve pain.

Possible Side Effects: 
Tiredness, dizziness, unsteady feeling, nausea, blurred vision.
Last updated on 02/01/2010

Ibuprofen


Trade Names: 
Advil®
Trade Names: 
Haltran®
Trade Names: 
Medipren®
Trade Names: 
Motrin®
Trade Names: 
Nuprin®
Trade Names: 
Profen®
Trade Names: 
Rufen®

Possible Uses: 
Relieve minor pain and pain associated with inflammation.

Possible Side Effects: 
Nausea, vomiting, bloody urine, stool or vomit, rash, red peeling skin, swelling in face or around the eyes, reduced kidney function, poor platelet function, liver toxicity, stomach pain, dizziness, ringing in ears, swelling in feet or legs. Used only when absolutely necessary, and then with great care, due to bleeding risks.
Last updated on 02/01/2010

Interleukin-eleven


Trade Names: 
Neumega®

Alternate Names: 
IL-eleven

Possible Uses: 
Speed platelet recovery after transplant.

Possible Side Effects: 
Fluid retention, heart rhythm abnormalities.
Last updated on 02/01/2010

Ketoconazole


Trade Names: 
Nizoral®

Possible Uses: 
Prevent or treat fungal infections, primarily in finger or toe nails.

Drug Interactions: 
This drug may interfer with many other drugs. Please check with your pharmacist

Possible Side Effects: 
Nausea, vomiting, diarrhea, headache, dizziness, drowsiness, rash, loss of appetite, yellow skin or eyes, dark colored urine, change in liver function.
Last updated on 02/01/2010

Mitoxantrone


Trade Names: 
Novantrone®

Possible Uses: 
Chemotherapy drug.

Possible Side Effects: 
Mouth sores, temporary hair loss, nausea, vomiting, diarrhea, blue-green discoloration of skin, urine and nail beds, reversible liver disorder, fever, chills, sore throat, heart damage, breathing difficulties, swollen feet or ankles, rash, itching.
Last updated on 02/01/2010

Naproxen


Trade Names: 
Aleve®
Trade Names: 
Anaprox®
Trade Names: 
Naprosyn®

Possible Uses: 
Relieve headaches, nerve and bone pain, and reduce inflammation.

Possible Side Effects: 
Nausea, vomiting, rash, swelling of face or around eyes, chest tightness, breathing difficulties, fever, sore throat, yellowing of skin or eyes, decreased urine output, stomach pain, bloody vomit, black or bloody stool, drowsiness, dizziness, ringing in ears, headache, heartburn, swollen feet or legs, constipation, diarrhea, stomach/intestinal bleeding, reduced kidney function, poor platelet function, liver toxicity. Used only when absolutely necessary, and then with great care, due to bleeding risks.
Last updated on 02/01/2010

Norfloxacin


Trade Names: 
Noroxin®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
Avoid calcium supplements, antacids, and dairy products one hour before or two hours after taking.

Possible Side Effects: 
Headache, dizziness, nausea, vomiting, diarrhea, change in liver or kidney function, sensitivity to sunlight, rash.
Last updated on 02/01/2010

Nystatin


Trade Names: 
Mycostatin®
Trade Names: 
Nilstat®

Possible Uses: 
Prevent or treat fungal infections in the mouth or on the skin.

Special Notes: 
When taken orally the drug works by being in contact with the mucous membranes. Swish in mouth for at least 30 seconds.

Possible Side Effects: 
Stomach upset, nausea, vomiting, diarrhea, change in taste.
Last updated on 02/01/2010

Oprelvekin


Trade Names: 
Neumega®

Alternate Names: 
IL-eleven

Possible Uses: 
Speed platelet recovery after transplant, though not approved by FDA

Possible Side Effects: 
Fluid retention, heart rhythm abnormalities, allergic reactions
Last updated on 02/01/2010

Pentamidine


Trade Names: 
Nebupent®
Trade Names: 
Pentacarinat®
Trade Names: 
Pentam®

Possible Uses: 
Can be given IV or inhalation to prevent protozoal infections.

Possible Side Effects: 
Decreased blood pressure, slow fast or irregular heartbeat, excessive hunger or thirst, nervousness, sweating, confusion, rash, itching, breathing difficulties, metallic taste, nausea, vomiting, decreased blood counts, decrease in blood sugar, change in kidney or liver function.
Last updated on 02/01/2010

Pentostatin


Trade Names: 
Nipent®

Possible Uses: 
Approved for hair cell leukemia but also used for chronic lymphocytic leukemia, T-Cell leukemia, and for acute Graft vs Host Disease

Drug Interactions: 
Echinacea

Possible Side Effects: 
Fevers, fatigue,chills, headache, rash,nausea, vomiting, diarrhea. Myleosuppression, anemia, and low platelets. Possible kidney and lung damage, as well as reactivation of previous viral infections.
Last updated on 02/01/2010

Posaconazole


Trade Names: 
Noxafil®

Possible Uses: 
Use to prevent or treat fungal infections

Special Notes: 
available only as an oral suspension.

Drug Interactions: 
This drug may interfer with many other drugs. Please check with your pharmacist. Avoid grapefuit juice and grapefruits.

Possible Side Effects: 
Diarrhea, headache, dizziness, fatigue,fever, low potassium levels,nausea, constipation, taste perversion,neutropenia, anemia, low platelets count, blurred vision.
Last updated on 02/01/2010

Tamoxifen


Trade Names: 
Nolvadex®

Possible Uses: 
Used primarily to treat breast cancer. May be used in some research protocols to determine if it prolongs remission after transplant.

Possible Side Effects: 
Fluid retention, swollen feet or ankles, nausea, vomiting, hot flashes, weight gain, vaginal discharge, irregular menstrual periods, drowsiness, rash, breathing difficulties, blurred vision, leg numbness or pain, blood clot.
Last updated on 02/01/2010

Tobramycin


Trade Names: 
Nebcin®

Possible Uses: 
Prevent or treat bacterial infection.

Possible Side Effects: 
Nausea, diarrhea, upset stomach, muscle weakness, twitching, decreased kidney function, dizziness, ringing in ears, hearing trouble. If patient is allergic, may cause breathing difficulties, rash, swelling of face, throat or lips.
Last updated on 02/01/2010
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