Welcome to the BMTInfonet Drug Database

This guide lists many of the drugs bone marrow, stem cell and cord blood transplants patients receive during treatment. It explains why they are used and some, but not allAcute lymphoblastic leukemia., of the possible side effects.

This guide should not be used as a substitute for a detailed discussion with your doctor and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.

Some of the drugs in this guide are also used outside the transplant setting. The descriptions of the drugs in this guide pertain only to their use in bone marrow, stem cell or cord blood transplantation.

If you are searching for a drug used by transplant patients and survivors that is not in this database, please contact us at drugdata@bmtinfonet.org.

This database was compiled under the direction of pharmacists knowledgeable about transplantation, but should not be construed as medical advice. Consult your doctor for information about how each drug might affect you.

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Doxorubicin


Trade Names: 
Doxil®
Trade Names: 
Adriamycin®
Trade Names: 
Rubex®

Possible Uses: 
A chemotherapy drug.

Drug Interactions: 
Inj. dexrazoxane can be given to prevent heart toxicities of doxorubicin.

Possible Side Effects: 
Decreased blood counts, temporary hair loss, mouth sores, loss of appetite, flu-like symptoms, heart damage, breathing difficulties, swelling in legs and feet, rash, itching, nausea, vomiting, diarrhea. May cause temporary orange or red color in urine and secretions (tears, mucous). When doxorubicin leaks outside the vein severe skin damage can occur.
Last updated on 02/01/2010

Ibuprofen


Trade Names: 
Advil®
Trade Names: 
Haltran®
Trade Names: 
Medipren®
Trade Names: 
Motrin®
Trade Names: 
Nuprin®
Trade Names: 
Profen®
Trade Names: 
Rufen®

Possible Uses: 
Relieve minor pain and pain associated with inflammation.

Possible Side Effects: 
Nausea, vomiting, bloody urine, stool or vomit, rash, red peeling skin, swelling in face or around the eyes, reduced kidney function, poor platelet function, liver toxicity, stomach pain, dizziness, ringing in ears, swelling in feet or legs. Used only when absolutely necessary, and then with great care, due to bleeding risks.
Last updated on 02/01/2010

Infliximab


Trade Names: 
Remicade®

Possible Uses: 
Approved to treat ulcerative colitis and rheumatoid arthritis. Unlabeld use in BMT is for severe GI tract GVHD not controlled by steroids

Special Notes: 
In GVHD treatment the drug can be given weekly for 4-8 weeks

Drug Interactions: 
Avoid echinacea

Possible Side Effects: 
Headache, nausea, diarrhea, stomach pain, infections,high blood pressure, rash, upset stomach, bronchitis, anemia,flushing.
Last updated on 02/01/2010

Interferon Alfa


Trade Names: 
Intron®
Trade Names: 
Roferon®

Alternate Names: 
IFN-A

Possible Uses: 
A commercially available drug that is used in an "off-label" use before and/or after transplants for patients with certain diseases to prolong remission. Also used with ribavirin to treat hepatitis C.

Possible Side Effects: 
Flu-like feeling, fatigue, fever, chills, muscle aches, loss of appetite, irregular heartbeat, numbness or tingling in hands or feet, nausea, vomiting, weight loss, dry mouth, dry throat, change in taste. Rarely, heart failure.
Last updated on 02/01/2010

Lenalidomide


Trade Names: 
Revlimid®

Possible Uses: 
myelodysplastic syndrome (MDS), multiple myeloma

Special Notes: 
Only available thru RevAssist distribution program (prescriber, pharmacist, and patient must be registered). Lenalidomide can cause severe or fatal birth defects. Two forms of birth control must be used. Blood or semen should not be donated during treatment. Breast feeding should be avoided.

Possible Side Effects: 
neutropenia, thrombocytopenia, increased risk of blood clots, nausea, vomiting, diarrhea, constipation
Last updated on 02/01/2010

Methotrexate


Trade Names: 
Folex PFS®
Trade Names: 
Rheumatrex®

Alternate Names: 
MTX

Possible Uses: 
Chemotherapy drug used in many cancers. Interfers with the way the body uses folic acid. Often used after a transplant to prevent graft vs host disease.

Drug Interactions: 
probeneicd, peniccillins. Folic aid, NSAIDs,

Possible Side Effects: 
Nausea, vomiting, diarrhea, temporary hair loss, mouth sores, headache, fever, chills, sore throat, loss of appetite, breathing difficulties, rash, itching, yellow eyes or skin, dark urine, decreased urine output.
Last updated on 02/01/2010

Morphine


Trade Names: 
MSContin®
Trade Names: 
MSIR®
Trade Names: 
Oramorph SR®
Trade Names: 
Roxanol®

Possible Uses: 
Relieve moderate to severe pain.

Possible Side Effects: 
Constipation, nausea, itching, vomiting, dizziness, weakness, dry mouth, headache, blurred vision, sleepiness, rapid or slow heartbeat, breathing difficulties, swollen face, rash, hallucinations, change in behavior, confusion, tender stomach.
Last updated on 02/01/2010

Oxycodone with acetaminophen


Trade Names: 
Percocet®
Trade Names: 
Roxicet®
Trade Names: 
Tylox®

Possible Uses: 
Relieve mild to moderate pain.

Possible Side Effects: 
Constipation, nausea, itching, vomiting, dizziness, weakness, dry mouth, headache, blurred vision, sleepiness, rapid or slow heartbeat, breathing difficulties, swollen face, rash, hallucinations, change in behavior, confusion, tender stomach.
Last updated on 02/01/2010

Ranitidine


Trade Names: 
Zantac®

Possible Uses: 
Reduce acid in the stomach, treat or prevent ulcers and reflux.

Possible Side Effects: 
Headache, dizziness, diarrhea, constipation, rash.
Last updated on 02/01/2010

Rasburicase


Trade Names: 
Elitek®

Possible Uses: 
Used to manage elevated uric acid levels in patients with a malignancy. Can be used to prevent elevated levels or treat elevated levels of uric acid.

Drug Interactions: 
no known significant interactions

Possible Side Effects: 
Rash, vomiting, nausea, constipation or diarrhea, mucositis, fever, headache
Last updated on 02/01/2010

Rifampin


Trade Names: 
Rifadin®
Trade Names: 
Rimactane®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
This drug interfers with many drugs. Please consult your pharmacist.

Possible Side Effects: 
Reddish color in urine, stool, tears or sweat, nausea, vomiting, diarrhea, loss of appetite, stomach cramps, rash, change in liver function.
Last updated on 02/01/2010

Rituximab


Trade Names: 
Rituxan®

Possible Uses: 
Use to treat non-Hodgkin's B-Cell lymphomas that express the CD-20 receptor on the tumor. The drug can also be used to treat graft vs host disease. Also approved to treat rheumatoid arthritis.

Drug Interactions: 
Echinacea

Possible Side Effects: 
Possible severe reactions during the infusion; mild nausea or vomiting,decreased white blood cells and platelets. Weakness,dizziness, anxiety, low blood pressure, diarrhea, back pain, muscle aches. Reactivation of previous viral infections.
Last updated on 02/01/2010

Sirolimus


Trade Names: 
Rapamune®

Possible Uses: 
Used during allogeneic transplant to prevent graft vs host disease. Dose may vary depending on blood levels of the drug.

Drug Interactions: 
This drug is dosed to achieve a specific blood level. Many drugs may decrease or increase these levels, please check with your pharmacist.

Possible Side Effects: 
peripheral edema, high blood pressure, chest pain, fever, headache, pain, insomnia, acne, high triglycerides, high cholestrol, low potassium and phosphorus,diarrhea, constipation, Nausea, vomiting, weight gain, anemia, and low platelets. Difficulty breathing, respiratory infections, and kidney damage.
Last updated on 02/01/2010

zoledronic acid


Trade Names: 
Zometa®
Trade Names: 
Reclast®

Possible Uses: 
Used to treat high calcium levels due to malignancy. Other uses include preventing/treating metastatic bone lesions for multiple myeloma patients and patients with solid tumors. Recently approved for treatment of osteoporosis

Special Notes: 
Patients should be taking a daily calcium supplement and multivitamin containing Vitamin D (if dietary intake is inadequate)

Drug Interactions: 
Thalidomide, and Ibuprofen type drugs, may increase the effects of zoledronic acid.

Possible Side Effects: 
Acute reaction within 3 days: fever, muscle or bone aches, flu-like symptoms. Leg edema, hypotension, fatigue, headache, dizziness, insomnia, hair loss, rash, nausea, constipation, vomiting, diarrhea, stomach pain, low white blood count, anemia, bone pain, weakness, decreased renal function.
Last updated on 02/01/2010
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