Welcome to the BMTInfonet Drug Database

This guide lists many of the drugs bone marrow, stem cell and cord blood transplants patients receive during treatment. It explains why they are used and some, but not allAcute lymphoblastic leukemia., of the possible side effects.

This guide should not be used as a substitute for a detailed discussion with your doctor and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.

Some of the drugs in this guide are also used outside the transplant setting. The descriptions of the drugs in this guide pertain only to their use in bone marrow, stem cell or cord blood transplantation.

If you are searching for a drug used by transplant patients and survivors that is not in this database, please contact us at drugdata@bmtinfonet.org.

This database was compiled under the direction of pharmacists knowledgeable about transplantation, but should not be construed as medical advice. Consult your doctor for information about how each drug might affect you.

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Acetaminophen


Trade Names: 
Tylenol®

Possible Uses: 
Relief of headaches and mild or moderate pain, or to decrease fevers.

Possible Side Effects: 
May mask a fever from an infection. May cause liver damage if dosage exceeds four grams per day.
Last updated on 02/01/2010

Amoxicillin


Trade Names: 
Amoxil®
Trade Names: 
Polymox®
Trade Names: 
Trimox®
Trade Names: 
Wymox®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
May decrease the effectiveness of oral contraceptives and increase the effects of anticoagulants such as warfarin or Coumadin®.

Possible Side Effects: 
Diarrhea, rash, nausea, and vomiting. If patient is allergic, may cause rash, swelling, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Ampicillin


Trade Names: 
Omnipen®
Trade Names: 
Polycillin®
Trade Names: 
Principen®
Trade Names: 
Totacillin®

Possible Uses: 
Prevent or treat bacterial infections.

Drug Interactions: 
May decrease the effectiveness of oral contraceptives and may increase the effects of anticoagulants such as warfarin or Coumadin®.

Possible Side Effects: 
Diarrhea, rash, nausea, vomiting. If patient has a penicillin allergy, may cause rash, swelling, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Antithymocyte Globulin


Trade Names: 
Atgam®
Trade Names: 
Thymogobulin®

Alternate Names: 
ATG
Alternate Names: 
Lymphocyte Immune Globulin

Possible Uses: 
Used in allogeneic transplants to treat or prevent graft-versus-host disease (GVHD).

Special Notes: 
Atgam is derived from horse serum and Thymoglobulin is derived from rabbit serum.

Possible Side Effects: 
Fever, chills, decreased or increased blood pressure, chest pain, fast heart beat, nausea, shortness of breath, diarrhea, irritation at injection site, decline in kidney function, swelling of mouth and throat.
Last updated on 02/01/2010

Calcium Carbonate


Trade Names: 
Caltrate®
Trade Names: 
Os-Cal®
Trade Names: 
Titralac®
Trade Names: 
Tums®

Possible Uses: 
Increase calcium, decrease phosphorous, acts as an antacid.

Special Notes: 
Should be taken 1-2 hours after other medications.

Drug Interactions: 
Many interactions including antibiotics and mycophenolate, check with your pharmacist.

Possible Side Effects: 
Diarrhea,vomiting, constipation or flatulence.
Last updated on 02/01/2010

Ceftazidime


Trade Names: 
Ceftaz®
Trade Names: 
Fortaz®
Trade Names: 
Tazidime®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Diarrhea, nausea, vomiting, pain and inflammation at injection site, fever, headache, rash, temporary increase in liver function tests, blurred vision. If patient is allergic, may cause rash, swelling, or breathing difficulties.
Last updated on 02/01/2010

Cimetidine


Trade Names: 
Tagamet®

Possible Uses: 
Decrease acid in the stomach, prevent or treat heartburn and ulcers.

Special Notes: 
Take with or immediately after meals. Take 1 hour before or 2 hours after antacids. Avoid excessive alcohol

Drug Interactions: 
Interacts with some drugs that are metabolized by the liver. Check with your pharmacist.

Possible Side Effects: 
Diarrhea, nausea, vomiting, dizziness, headache, drowsiness.
Last updated on 02/01/2010

Docetaxel


Trade Names: 
Taxotere®

Possible Uses: 
A chemotherapy drug.

Special Notes: 
Dexamethasone is required to be taken for 3 days when receiving this drug. It is used to reduce/prevent side effects from docetaxel.

Possible Side Effects: 
Decreased blood counts, weakness, fatigue, mild nausea or vomiting, tingling or pain in arms and/or legs, fluid in arms and/or legs, rash, change in fingernails (usually darkening and yellowing), temporary hair loss, irritation at injection site. Rarely, separation of nails from fingers. Nails regrow when drug is discontinued.
Last updated on 02/01/2010

Imipramine


Trade Names: 
Tofranil®

Possible Uses: 
Control depression and nerve pain.

Possible Side Effects: 
Dry mouth, constipation, confusion, sleepiness, low blood pressure, heart rhythm changes, rash, difficulty urinating, dizziness, nausea, vision problems. May suppress stem cell engraftment.
Last updated on 02/01/2010

Leucovorin


Trade Names: 
Wellcovorin®

Alternate Names: 
Tetra-hydrofolate

Possible Uses: 
This drug is a folic acid derviative. Used to rescue cells from excess methotrexate blood levels.

Possible Side Effects: 
Flushed face, warm feeling.
Last updated on 02/01/2010

Oxycodone with acetaminophen


Trade Names: 
Percocet®
Trade Names: 
Roxicet®
Trade Names: 
Tylox®

Possible Uses: 
Relieve mild to moderate pain.

Possible Side Effects: 
Constipation, nausea, itching, vomiting, dizziness, weakness, dry mouth, headache, blurred vision, sleepiness, rapid or slow heartbeat, breathing difficulties, swollen face, rash, hallucinations, change in behavior, confusion, tender stomach.
Last updated on 02/01/2010

Paclitaxel


Trade Names: 
Taxol®

Possible Uses: 
A chemotherapy drug. Originally developed from the pacific Yew Tree

Special Notes: 
Antihistamines(Benadryl & cimetidine) and steroids (dexamethasone) must be given before this drug to prevent hypersensitivity reactions.

Possible Side Effects: 
Nausea, vomiting, diarrhea, constipation, fever, chills, mouth sores, numbness and/or tingling in fingers and toes that may progress to hands, lower arms and feet, nerve pain, bone pain, muscle pain, tiredness, loss of appetite, temporary hair loss, heartbeat irregularities. If patient is allergic, may cause swollen face, lips or throat, breathing difficulties, lowered blood pressure. Rarely, separation of the nails from fingers. Nails re-grow when drug is discontinued.
Last updated on 02/01/2010

Tacrolimus


Trade Names: 
Prograf®

Possible Uses: 
Use orally or IV in allogeneic transplantation to prevent/treat graft vs host disease.

Drug Interactions: 
This drug is dosed to achieve a specific blood level. Many drugs may decrease or increase these levels, please check with your pharmacist.

Possible Side Effects: 
Decreased kidney function, tremor, diarrhea, nause, vomiting, abdominal discomfort, glucose intolerance (high doses)
Last updated on 02/01/2010

Tamoxifen


Trade Names: 
Nolvadex®

Possible Uses: 
Used primarily to treat breast cancer. May be used in some research protocols to determine if it prolongs remission after transplant.

Possible Side Effects: 
Fluid retention, swollen feet or ankles, nausea, vomiting, hot flashes, weight gain, vaginal discharge, irregular menstrual periods, drowsiness, rash, breathing difficulties, blurred vision, leg numbness or pain, blood clot.
Last updated on 02/01/2010

Thalidomide


Trade Names: 
Thalomid®

Possible Uses: 
Approved for use in multiple myeloma but also used in graft vs host disease.

Special Notes: 
Only available thru STEPS program (prescriber, pharmacist, and patient must be registered). Thalidomide can cause severe or fatal birth defects. Two forms of birth control must be used. Blood or semen should not be donated during treatment. Breast feeding should be avoided.

Drug Interactions: 
Cat's Claw, Echinacea

Possible Side Effects: 
Edema, hypotension,fatigue, drowsiness, dizziness, headache, rash, neutropenia, anemia, increased risk of blood clots, nausea, vomiting, diarrhea, constipation, muscle weakness, tremor, muscle aches, numbness in hands or feet.
Last updated on 02/01/2010

Thiotepa


Trade Names: 
Thiotepa®

Possible Uses: 
Chemotherapy drug.

Possible Side Effects: 
Nausea, vomiting, temporary hair loss, rash, mouth sores, infertility, reversible liver disorder, irregular menstrual periods, loss of appetite, weakness, headache, dizziness, fever. If patient is allergic, decreased blood pressure, fever, breathing difficulties, swelling.
Last updated on 02/01/2010

Ticarcillin


Trade Names: 
Ticar®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Nausea, vomiting, diarrhea, rash, bleeding problems, change in kidney or liver function. If patient is allergic, may cause swollen face, throat or lips, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Ticarcillin/clavulinate


Trade Names: 
Timentin®

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Nausea, vomiting, diarrhea, rash, bleeding problems, change in kidney or liver function. If patient is allergic, may cause swollen face, throat or lips, breathing difficulties. May also cause a superinfection such as vaginal fungal infection.
Last updated on 02/01/2010

Tobramycin


Trade Names: 
Nebcin®

Possible Uses: 
Prevent or treat bacterial infection.

Possible Side Effects: 
Nausea, diarrhea, upset stomach, muscle weakness, twitching, decreased kidney function, dizziness, ringing in ears, hearing trouble. If patient is allergic, may cause breathing difficulties, rash, swelling of face, throat or lips.
Last updated on 02/01/2010

Topotecan


Trade Names: 
Hycamtin®

Possible Uses: 
A chemotherapy drug.

Possible Side Effects: 
Dizziness, trouble standing, ringing in ears, hearing trouble, rash, swollen face, throat or lips, breathing difficulties, decreased urine output, diarrhea, muscle twitching or weakness, nausea, upset stomach.
Last updated on 02/01/2010

Trimethoprim/sulfamethoxazole


Trade Names: 
Bactrim®
Trade Names: 
Bactrim DS®
Trade Names: 
Septra®
Trade Names: 
Uroplus®

Alternate Names: 
TMP/SMX

Possible Uses: 
Prevent or treat bacterial infections.

Possible Side Effects: 
Rash, nausea, vomiting, diarrhea, stomach upset, decreased blood counts, change in kidney or liver function. If patient is allergic, may cause breathing difficulties, swelling of face, throat or lips.
Last updated on 02/01/2010