Symptoms

Sometimes chronic GVHD affects the nervous system. Symptoms may include:

• numbness or a painful, tingling sensation in your hands and/or feet
• a shooting pain in your hands and/or feet
• lack of coordination

These problems, caused by nerve damage, are called neuropathy.

Treatment

Depending on the severity, neuropathy may be treated with:

• a topical medication such as a lidocaine patch or gel
• oral medications such as amitriptyline, gabapentin or pregabalin
• physical and occupational therapy
• soaking feet in cool water

Take Action!

• Talk to your doctor if you have symptoms of neuropathy. A consultation with a neurologist can help.
• Wash your feet daily with lukewarm water and fragrance-free soap.
• Inspect your feet daily for cuts, bruises, cracking or other changes that may require attention.
• Wear sturdy shoes or slippers at all times.
• Do not apply direct heat to your feet and legs.
• Avoid falls:
  
  • Keep your home free of clutter and slippery surfaces.
  • Consider using devices, such as handrails and canes, to help maintain your balance.

Watch this video about managing neuropathy after transplant. Click here [1] to view a transcript of this video and download the slides. 

#GVHD

If you use social media, learn more about living with graft-versus-host disease and advances in treatment at #GVHD. Connect with others and show your support for GVHD patients.

(To view this page in Spanish click here [2].)

Next page:  Infection and GVHD [3]

Updated August 2023